Reaction Details Report a problem with these data
Target
Mitogen-activated protein kinase 14
Ligand
BDBM50174089
Substrate
n/a
Meas. Tech.
ChEMBL_326792 (CHEMBL860117)
IC50
16000±n/a nM
Citation
 Michelotti, EL; Moffett, KK; Nguyen, D; Kelly, MJ; Shetty, R; Chai, X; Northrop, K; Namboodiri, V; Campbell, B; Flynn, GA; Fujimoto, T; Hollinger, FP; Bukhtiyarova, M; Springman, EB; Karpusas, M Two classes of p38alpha MAP kinase inhibitors having a common diphenylether core but exhibiting divergent binding modes. Bioorg Med Chem Lett 15:5274-9 (2005) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50174089
Synonyms:
4-(2-hydroxybenzylamino)-N-(3-phenoxyphenyl)piperidine-1-sulfonamide | CHEMBL197336
Type:
Small organic molecule
Emp. Form.:
C24H27N3O4S
Mol. Mass.:
453.554
SMILES:
Oc1ccccc1CNC1CCN(CC1)S(=O)(=O)Nc1cccc(Oc2ccccc2)c1
Structure:
Search PDB for entries with ligand similarity: