Reaction Details Report a problem with these data
Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM80642
Substrate
n/a
Meas. Tech.
ChEMBL_2223583 (CHEMBL5136917)
IC50
109±n/a nM
Citation
Bavo, F; Pallavicini, M; Pucci, S; Appiani, R; Giraudo, A; Eaton, B; Lucero, L; Gotti, C; Moretti, M; Whiteaker, P; Bolchi, C From 2-Triethylammonium Ethyl Ether of 4-Stilbenol (MG624) to Selective Small-Molecule Antagonists of Human ?9?10 Nicotinic Receptor by Modifications at the Ammonium Ethyl Residue. J Med Chem 65:10079-10097 (2022) [PubMed]
More Info.:
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_CHICK | CHRNA7
Type:
PROTEIN
Mol. Mass.:
56940.23
Organism:
Gallus gallus
Description:
ChEMBL_120662
Residue:
502
Sequence:
MGLRALMLWLLAAAGLVRESLQGEFQRKLYKELLKNYNPLERPVANDSQPLTVYFTLSLMQIMDVDEKNQVLTTNIWLQMYWTDHYLQWNVSEYPGVKNVRFPDGLIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQKCNLKFGSWTYGGWSLDLQMQEADISGYISNGEWDLVGIPGKRTESFYECCKEPYPDITFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLSSMEMNTVSGQQCSNGNMLYIGFRGLDGVHCTPTTDSGVICGRMTCSPTEEENLLHSGHPSEGDPDLAKILEEVRYIANRFRDQDEEEAICNEWKFAASVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
Inhibitor
Name:
BDBM80642
Synonyms:
CHEMBL191491 | MG 624 | MLS002172460 | SMR001254093 | cid_6433339 | triethyl-[2-[4-[(E)-2-phenylethenyl]phenoxy]ethyl]ammonium;iodide | triethyl-[2-[4-[(E)-2-phenylethenyl]phenoxy]ethyl]azanium;iodide | triethyl-[2-[4-[(E)-styryl]phenoxy]ethyl]ammonium;iodide
Type:
Small organic molecule
Emp. Form.:
C22H30NO
Mol. Mass.:
324.4792
SMILES:
CC[N+](CC)(CC)CCOc1ccc(\C=C\c2ccccc2)cc1