Target
L-lactate dehydrogenase A chain
Ligand
BDBM50597902
Substrate
n/a
Meas. Tech.
ChEMBL_2224765 (CHEMBL5138278)
IC50
4.0±n/a nM
Citation
 Wei, BRobarge, KLabadie, SSChen, JCorson, LBDiPasquale, ADragovich, PSEigenbrot, CEvangelista, MFauber, BPHitz, AHong, RLai, KWLiu, WMa, SMalek, SO'Brien, TPang, JPeterson, DSalphati, LSampath, DSideris, SUltsch, MXu, ZYen, IYu, DYue, QZhou, APurkey, HE Structure-based optimization of hydroxylactam as potent, cell-active inhibitors of lactate dehydrogenase. Bioorg Med Chem Lett 59:0 (2022) [PubMed] 
Target
Name:
L-lactate dehydrogenase A chain
Synonyms:
Cell proliferation-inducing gene 19 protein | L-lactate dehydrogenase A | L-lactate dehydrogenase A Chain | LDH muscle subunit | LDH-A | LDH-M | LDHA | LDHA_HUMAN | Lactate dehydrogenase A (LDHA) | Renal carcinoma antigen NY-REN-59
Type:
Protein
Mol. Mass.:
36694.85
Organism:
Homo sapiens (Human)
Description:
P00338::PDB Code: 4ajp
Residue:
332
Sequence:
MATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGISDLVKVTLTSEEEARLKKSADTLWGIQKELQF
  
Inhibitor
Name:
BDBM50597902
Synonyms:
CHEMBL5177632
Type:
Small organic molecule
Emp. Form.:
C27H19ClFNO3S2
Mol. Mass.:
524.026
SMILES:
OC1=C(Sc2ccccc2Cl)C(=O)O[C@@](C1)(c1ccsc1)c1cccc(Nc2ccc(F)cc2)c1 |r,c:1|
Structure:
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