Reaction Details Report a problem with these data
Target
Gag-Pol polyprotein [489-587]
Ligand
BDBM50174973
Substrate
n/a
Meas. Tech.
ChEMBL_326591 (CHEMBL862987)
IC50
1.2±n/a nM
Citation
Zhao, C; Sham, HL; Sun, M; Stoll, VS; Stewart, KD; Lin, S; Mo, H; Vasavanonda, S; Saldivar, A; Park, C; McDonald, EJ; Marsh, KC; Klein, LL; Kempf, DJ; Norbeck, DW Synthesis and activity of N-acyl azacyclic urea HIV-1 protease inhibitors with high potency against multiple drug resistant viral strains. Bioorg Med Chem Lett 15:5499-503 (2005) [PubMed] Article
More Info.:
Target
Name:
Gag-Pol polyprotein [489-587]
Synonyms:
Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
10781.16
Organism:
Human immunodeficiency virus type 1
Description:
P04585[489-587]
Residue:
99
Sequence:
PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
Inhibitor
Name:
BDBM50174973
Synonyms:
(5R,6R)-2,4-bis(4-hydroxy-3-methoxybenzyl)-5-benzyl-6-hydroxy-1-(3-(pyridin-4-yl)propanoyl)-1,2,4-triazepan-3-one | CHEMBL371085
Type:
Small organic molecule
Emp. Form.:
C35H38N4O7
Mol. Mass.:
626.6988
SMILES:
COc1cc(CN2[C@H](Cc3ccccc3)[C@H](O)CN(N(Cc3ccc(O)c(OC)c3)C2=O)C(=O)CCc2ccncc2)ccc1O