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Target
P2X purinoceptor 4
Ligand
BDBM50598326
Substrate
n/a
Meas. Tech.
ChEMBL_2226719 (CHEMBL5140232)
IC50
39±n/a nM
Citation
 Mahmood, A; Villinger, A; Iqbal, J Therapeutic potentials and structure-activity relationship of 1,3-benzodioxole N-carbamothioyl carboxamide derivatives as selective and potent antagonists of P2X4 and P2X7 receptors. Eur J Med Chem 238:0 (2022) [PubMed] 
Target
Name:
P2X purinoceptor 4
Synonyms:
ATP receptor | P2RX4 | P2RX4_HUMAN | P2X4 | Purinergic receptor | Purinergic, P2X4
Type:
Enzyme Catalytic Domain
Mol. Mass.:
43374.70
Organism:
Homo sapiens (Human)
Description:
Purinergic, P2X4 0 HUMAN::Q99571
Residue:
388
Sequence:
MAGCCAALAAFLFEYDTPRIVLIRSRKVGLMNRAVQLLILAYVIGWVFVWEKGYQETDSVVSSVTTKVKGVAVTNTSKLGFRIWDVADYVIPAQEENSLFVMTNVILTMNQTQGLCPEIPDATTVCKSDASCTAGSAGTHSNGVSTGRCVAFNGSVKTCEVAAWCPVEDDTHVPQPAFLKAAENFTLLVKNNIWYPKFNFSKRNILPNITTTYLKSCIYDAKTDPFCPIFRLGKIVENAGHSFQDMAVEGGIMGIQVNWDCNLDRAASLCLPRYSFRRLDTRDVEHNVSPGYNFRFAKYYRDLAGNEQRTLIKAYGIRFDIIVFGKAGKFDIIPTMINIGSGLALLGMATVLCDIIVLYCMKKRLYYREKKYKYVEDYEQGLASELDQ
  
Inhibitor
Name:
BDBM50598326
Synonyms:
CHEMBL5206892
Type:
Small organic molecule
Emp. Form.:
C18H17BrN2O3S
Mol. Mass.:
421.308
SMILES:
CC(C)c1ccc(NC(=S)NC(=O)c2ccc3OCOc3c2)c(Br)c1
Structure:
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