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Target
Peroxisome proliferator-activated receptor alpha
Ligand
BDBM50175262
Substrate
n/a
Meas. Tech.
ChEMBL_328557 (CHEMBL869428)
EC50
>100000±n/a nM
Citation
 Coppola, GM; Damon, RE; Eskesen, JB; France, DS; Paterniti, JR Biological evaluation of 1-alkyl-3-phenylthioureas as orally active HDL-elevating agents. Bioorg Med Chem Lett 16:113-7 (2005) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor alpha
Synonyms:
Nr1c1 | Nuclear receptor subfamily 1 group C member 1 | PPAR-alpha | PPARA_RAT | Peroxisome Proliferator-Activated Receptor alpha | Ppar | Ppara
Type:
PROTEIN
Mol. Mass.:
52374.28
Organism:
Rattus norvegicus
Description:
ChEMBL_834194
Residue:
468
Sequence:
MVDTESPICPLSPLEADDLESPLSEEFLQEMGNIQEISQSLGEESSGSFSFADYQYLGSCPGSEGSVITDTLSPASSPSSVSCPAVPTSTDESPGNALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLAYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDLKDSETADLKSLAKRIHEAYLKNFNMNKVKARVILAGKTSNNPPFVIHDMETLCMAEKTLVAKMVANGVENKEAEVRFFHCCQCMSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFTMLSSLMNKDGMLIAYGNGFITREFLKNLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNIGYIEKLQEGIVHVLKLHLQSNHPDDTFLFPKLLQKMVDLRQLVTEHAQLVQVIKKTESDAALHPLLQEIYRDMY
  
Inhibitor
Name:
BDBM50175262
Synonyms:
(S)-N-(5-chloro-2-methylphenyl)-2-ethylpiperidine-1-carbothioamide | CHEMBL199490
Type:
Small organic molecule
Emp. Form.:
C15H21ClN2S
Mol. Mass.:
296.859
SMILES:
CC[C@H]1CCCCN1C(=S)Nc1cc(Cl)ccc1C
Structure:
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