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Target
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma
Ligand
BDBM50599600
Substrate
n/a
Meas. Tech.
ChEMBL_2231147 (CHEMBL5144919)
IC50
16000±n/a nM
Citation
 Andrews, DM; Cartic, S; Cosulich, S; Divecha, N; Faulder, P; Flemington, V; Kern, O; Kettle, JG; MacDonald, E; McKelvie, J; Pike, KG; Roberts, B; Rowlinson, R; Smith, JM; Stockley, M; Swarbrick, ME; Treinies, I; Waring, MJ Identification and optimization of a novel series of selective PIP5K inhibitors. Bioorg Med Chem 54:0 (2022) [PubMed] 
Target
Name:
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma
Synonyms:
KIAA0589 | PI51C_HUMAN | PIP5K1-gamma | PIP5K1C | PIP5KIgamma | Phosphatidylinositol 4-phosphate 5-kinase type I gamma | Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma | Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma | PtdIns(4)P-5-kinase 1 gamma
Type:
PROTEIN
Mol. Mass.:
73241.99
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1508846
Residue:
668
Sequence:
MELEVPDEAESAEAGAVPSEAAWAAESGAAAGLAQKKAAPTEVLSMTAQPGPGHGKKLGHRGVDASGETTYKKTTSSTLKGAIQLGIGYTVGHLSSKPERDVLMQDFYVVESIFFPSEGSNLTPAHHFQDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCNEPLIELSNPGASGSLFYVTSDDEFIIKTVMHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQSGGKNIRVVVMNNILPRVVKMHLKFDLKGSTYKRRASKKEKEKSFPTYKDLDFMQDMPEGLLLDADTFSALVKTLQRDCLVLESFKIMDYSLLLGVHNIDQHERERQAQGAQSTSDEKRPVGQKALYSTAMESIQGGAARGEAIESDDTMGGIPAVNGRGERLLLHIGIIDILQSYRFIKKLEHTWKALVHDGDTVSVHRPSFYAERFFKFMSNTVFRKNSSLKSSPSKKGRGGALLAVKPLGPTAAFSASQIPSEREEAQYDLRGARSYPTLEDEGRPDLLPCTPPSFEEATTASIATTLSSTSLSIPERSPSETSEQPRYRRRTQSSGQDGRPQEEPPAEEDLQQITVQVEPACSVEIVVPKEEDAGVEASPAGASAAVEVETASQASDEEGAPASQASDEEDAPATDIYFPTDERSWVYSPLHYSAQAPPASDGESDT
  
Inhibitor
Name:
BDBM50599600
Synonyms:
CHEMBL5178781
Type:
Small organic molecule
Emp. Form.:
C18H19N3O3
Mol. Mass.:
325.3618
SMILES:
CC(=O)Nc1cccc(c1)-c1ccnc(NC(=O)C2CCOC2)c1
Structure:
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