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Target
Integrase
Ligand
BDBM50178733
Substrate
n/a
Meas. Tech.
ChEMBL_326393 (CHEMBL867584)
IC50
17000±n/a nM
Citation
 Dayam, R; Sanchez, T; Neamati, N Diketo acid pharmacophore. 2. Discovery of structurally diverse inhibitors of HIV-1 integrase. J Med Chem 48:8009-15 (2005) [PubMed]  Article 
Target
Name:
Integrase
Synonyms:
Human immunodeficiency virus type 1 integrase
Type:
PROTEIN
Mol. Mass.:
32231.48
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_90865
Residue:
288
Sequence:
FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED
  
Inhibitor
Name:
BDBM50178733
Synonyms:
4-((2-benzoyl-4-bromophenyl)carbamoyl)-1H-imidazole-5-carboxylic acid | CHEMBL382489
Type:
Small organic molecule
Emp. Form.:
C18H12BrN3O4
Mol. Mass.:
414.21
SMILES:
OC(=O)c1nc[nH]c1C(=O)Nc1ccc(Br)cc1C(=O)c1ccccc1
Structure:
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