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Target
Prostaglandin G/H synthase 2
Ligand
BDBM50137425
Substrate
n/a
Meas. Tech.
ChEMBL_336080 (CHEMBL865931)
IC50
310±n/a nM
Citation
Sakya, SM; Cheng, H; Lundy Demello, KM; Shavnya, A; Minich, ML; Rast, B; Dutra, J; Li, C; Rafka, RJ; Koss, DA; Li, J; Jaynes, BH; Ziegler, CB; Mann, DW; Petras, CF; Seibel, SB; Silvia, AM; George, DM; Hickman, A; Haven, ML; Lynch, MP 5-Heteroatom-substituted pyrazoles as canine COX-2 inhibitors: Part 2. Structure-activity relationship studies of 5-alkylethers and 5-thioethers. Bioorg Med Chem Lett 16:1202-6 (2006) [PubMed] Article
More Info.:
Target
Name:
Prostaglandin G/H synthase 2
Synonyms:
Cyclooxygenase-2 | Prostaglandin G/H synthase-2
Type:
PROTEIN
Mol. Mass.:
68982.35
Organism:
Canis familiaris
Description:
ChEMBL_344386
Residue:
604
Sequence:
MLARALVLCAALAVVRAANPCCSHPCQNQGICMSTGFDQYKCDCTRTGFYGENCSTPEFLTRIKLYLKPTPNTVHYILTHFKGVWNIVNNIPFLRNTIMKYVLTSRSHLIESPPTYNVNYGYKSWEAFSNLSYYTRALPPVPDDCPTPMGVKGKKELPDSKEIVEKFLLRRKFIPDPQGTNMMFAFFAQHFTHQFFKTDHKRGPAFTKGLGHGVDLNHVYGETLDRQHKLRLFKDGKMKYQVIDGEVYPPTVKDTQVEMIYPPHVPEHLQFAVGQEVFGLVPGLMMYATIWLREHNRVCDVLKQEHPEWDDERLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNQQFQYQNRIAAEFNTLYHWHPLLPDTLQIDDQEYNFQQFIYNNSILLEHGLTQFVESFSRQIAGRVAGGRNVPAAVQQVAKASIDQSRQMKYQSLNEYRKRFRLKPYTSFEELTGEKEMAAGLEALYGDIDAMELYPALLVEKPRPDAIFGETMVEMGAPFSLKGLMGNPICSPDYWKPSTFGGEVGFKIINTASIQSLICNNVKGCPFTAFSVQDGQLTKTVTINASSSHSGLDDINPTVLLKERSTEL
Inhibitor
Name:
BDBM50137425
Synonyms:
2-(3-(difluoromethyl)-5-phenyl-1H-pyrazol-1-yl)-5-(methylsulfonyl)pyridine | 2-(3-Difluoromethyl-5-phenyl-pyrazol-1-yl)-5-methanesulfonyl-pyridine | CHEMBL174219
Type:
Small organic molecule
Emp. Form.:
C16H13F2N3O2S
Mol. Mass.:
349.355
SMILES:
CS(=O)(=O)c1ccc(nc1)-n1nc(cc1-c1ccccc1)C(F)F