Reaction Details Report a problem with these data
Target
Vasopressin V2 receptor
Ligand
BDBM50600600
Substrate
n/a
Meas. Tech.
ChEMBL_2234600 (CHEMBL5148372)
Ki
4.3±n/a nM
Citation
 Cao, X; Wang, P; Yuan, H; Zhang, H; He, Y; Fu, K; Fang, Q; Liu, H; Su, L; Yin, L; Xu, P; Xie, Y; Xiong, X; Wang, J; Zhu, X; Guo, D Benzodiazepine Derivatives as Potent Vasopressin V J Med Chem 65:9295-9311 (2022) [PubMed] 
Target
Name:
Vasopressin V2 receptor
Synonyms:
ADHR | AVPR V2 | AVPR2 | Antidiuretic hormone receptor | DIR | DIR3 | Renal-type arginine vasopressin receptor | V2R | V2R_HUMAN | VASOPRESSIN V2 | Vasopressin V2 receptor | Vasopressin receptor
Type:
Receptor
Mol. Mass.:
40295.28
Organism:
Homo sapiens (Human)
Description:
P30518
Residue:
371
Sequence:
MLMASTTSAVPGHPSLPSLPSNSSQERPLDTRDPLLARAELALLSIVFVAVALSNGLVLAALARRGRRGHWAPIHVFIGHLCLADLAVALFQVLPQLAWKATDRFRGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGSGAHWNRPVLVAWAFSLLLSLPQLFIFAQRNVEGGSGVTDCWACFAEPWGRRTYVTWIALMVFVAPTLGIAACQVLIFREIHASLVPGPSERPGGRRRGRRTGSPGEGAHVSAAVAKTVRMTLVIVVVYVLCWAPFFLVQLWAAWDPEAPLEGAPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCARGRTPPSLGPQDESCTTASSSLAKDTSS
  
Inhibitor
Name:
BDBM50600600
Synonyms:
CHEMBL5207885
Type:
Small organic molecule
Emp. Form.:
C36H38N4O3
Mol. Mass.:
574.7119
SMILES:
O=C(Nc1ccc(cc1)C(=O)N1CCCN(CCCN2CCOCC2)c2ccccc12)c1ccccc1-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: