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Target
Melanocortin receptor 4
Ligand
BDBM50182062
Substrate
n/a
Meas. Tech.
ChEMBL_348051 (CHEMBL868466)
Ki
26±n/a nM
Citation
 Vos, TJ; Balani, S; Blackburn, C; Chau, RW; Danca, MD; Drabic, SV; Farrer, CA; Patane, MA; Stroud, SG; Yowe, DL; Claiborne, CF Identification and structure-activity relationships of a new series of Melanocortin-4 receptor antagonists. Bioorg Med Chem Lett 16:2302-5 (2006) [PubMed]  Article 
Target
Name:
Melanocortin receptor 4
Synonyms:
MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R)
Type:
Enzyme
Mol. Mass.:
36949.50
Organism:
Homo sapiens (Human)
Description:
P32245
Residue:
332
Sequence:
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
  
Inhibitor
Name:
BDBM50182062
Synonyms:
CHEMBL205214 | N-{2-[2-(5-bromo-2-methoxy-phenyl)-ethyl]-3-fluoro-benzoyl}-N'-[4-(3,4-dihydro-1H-isoquinolin-2-yl)-butyl]-guanidine
Type:
Small organic molecule
Emp. Form.:
C30H34BrFN4O2
Mol. Mass.:
581.519
SMILES:
COc1ccc(Br)cc1CCc1c(F)cccc1C(=O)NC(N)=NCCCCN1CCc2ccccc2C1 |w:23.25|
Structure:
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