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Target
Melanocortin receptor 4
Ligand
BDBM50182068
Substrate
n/a
Meas. Tech.
ChEMBL_348051 (CHEMBL868466)
Ki
11±n/a nM
Citation
 Vos, TJ; Balani, S; Blackburn, C; Chau, RW; Danca, MD; Drabic, SV; Farrer, CA; Patane, MA; Stroud, SG; Yowe, DL; Claiborne, CF Identification and structure-activity relationships of a new series of Melanocortin-4 receptor antagonists. Bioorg Med Chem Lett 16:2302-5 (2006) [PubMed]  Article 
Target
Name:
Melanocortin receptor 4
Synonyms:
MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R)
Type:
Enzyme
Mol. Mass.:
36949.50
Organism:
Homo sapiens (Human)
Description:
P32245
Residue:
332
Sequence:
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
  
Inhibitor
Name:
BDBM50182068
Synonyms:
CHEMBL208376 | N-{2-[2-(5-bromo-2-methoxy-phenyl)-ethyl]-thiophene-3-carbonyl}-N'-(4-diethylamino-1-methyl-butyl)-guanidine
Type:
Small organic molecule
Emp. Form.:
C24H35BrN4O2S
Mol. Mass.:
523.529
SMILES:
CCN(CC)CCCC(C)N=C(N)NC(=O)c1ccsc1CCc1cc(Br)ccc1OC |w:10.9|
Structure:
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