Reaction Details Report a problem with these data
Target
Melanocortin receptor 4
Ligand
BDBM50182070
Substrate
n/a
Meas. Tech.
ChEMBL_348051 (CHEMBL868466)
Ki
89±n/a nM
Citation
 Vos, TJ; Balani, S; Blackburn, C; Chau, RW; Danca, MD; Drabic, SV; Farrer, CA; Patane, MA; Stroud, SG; Yowe, DL; Claiborne, CF Identification and structure-activity relationships of a new series of Melanocortin-4 receptor antagonists. Bioorg Med Chem Lett 16:2302-5 (2006) [PubMed]  Article 
Target
Name:
Melanocortin receptor 4
Synonyms:
MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R)
Type:
Enzyme
Mol. Mass.:
36949.50
Organism:
Homo sapiens (Human)
Description:
P32245
Residue:
332
Sequence:
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
  
Inhibitor
Name:
BDBM50182070
Synonyms:
CHEMBL205553 | N-(4-diethylamino-1-methyl-butyl)-N'-[3-fluoro-2-(2-naphthalen-1-yl-ethyl)-benzoyl]-guanidine
Type:
Small organic molecule
Emp. Form.:
C29H37FN4O
Mol. Mass.:
476.6287
SMILES:
CCN(CC)CCCC(C)N=C(N)NC(=O)c1cccc(F)c1CCc1cccc2ccccc12 |w:10.9|
Structure:
Search PDB for entries with ligand similarity: