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Target
Cytochrome P450 2C19
Ligand
BDBM50183183
Substrate
n/a
Meas. Tech.
ChEMBL_354703 (CHEMBL853123)
IC50
>50000±n/a nM
Citation
 Hall, A; Bit, RA; Brown, SH; Chaignot, HM; Chessell, IP; Coleman, T; Giblin, GM; Hurst, DN; Kilford, IR; Lewell, XQ; Michel, AD; Mohamed, S; Naylor, A; Novelli, R; Skinner, L; Spalding, DJ; Tang, SP; Wilson, RJ Discovery of novel biaryl heterocyclic EP1 receptor antagonists. Bioorg Med Chem Lett 16:2666-71 (2006) [PubMed]  Article 
Target
Name:
Cytochrome P450 2C19
Synonyms:
(R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | (S)-limonene 7-monooxygenase | CP2CJ_HUMAN | CYP2C19 | CYPIIC17 | CYPIIC19 | Cytochrome P450 2C19 (CYP2C19) | Cytochrome P450 2C19 [I331V] | Cytochrome P450-11A | Cytochrome P450-254C | Fenbendazole monooxygenase (4'-hydroxylating) | Mephenytoin 4-hydroxylase | P450-11A | P450-254C
Type:
Enzyme
Mol. Mass.:
55935.47
Organism:
Homo sapiens (Human)
Description:
P33261
Residue:
490
Sequence:
MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQLCFIPV
  
Inhibitor
Name:
BDBM50183183
Synonyms:
3-(3-(2-(benzyloxy)-5-chlorophenyl)pyridin-2-yl)benzoic acid | CHEMBL206096
Type:
Small organic molecule
Emp. Form.:
C25H18ClNO3
Mol. Mass.:
415.868
SMILES:
OC(=O)c1cccc(c1)-c1ncccc1-c1cc(Cl)ccc1OCc1ccccc1
Structure:
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