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Target
5-hydroxytryptamine receptor 2C
Ligand
BDBM50184590
Substrate
n/a
Meas. Tech.
ChEMBL_365289 (CHEMBL862275)
EC50
319±n/a nM
Citation
 Huck, BR; Llamas, L; Robarge, MJ; Dent, TC; Song, J; Hodnick, WF; Crumrine, C; Stricker-Krongrad, A; Harrington, J; Brunden, KR; Bennani, YL The identification of pyrimidine-diazabicyclo[3.3.0]octane derivatives as 5-HT2C receptor agonists. Bioorg Med Chem Lett 16:2891-4 (2006) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 2C
Synonyms:
5-HT-1C | 5-HT-2C | 5-HT1C | 5-HT2C | 5-HT2C-INI | 5-HT2c VGI | 5-HTR2C | 5-hydroxytryptamine receptor 1C | 5-hydroxytryptamine receptor 2C (5-HT-2C) | 5-hydroxytryptamine receptor 2C (5HT-2C) | 5HT-1C | 5HT2C_HUMAN | HTR1C | HTR2C | Serotonin (5-HT3) receptor | Serotonin 2c (5-HT2c) receptor | Serotonin Receptor 2C
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
51836.79
Organism:
Homo sapiens (Human)
Description:
P28335
Residue:
458
Sequence:
MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV
  
Inhibitor
Name:
BDBM50184590
Synonyms:
(3aS,6aS)-1-(3-fluorophenyl)-octahydropyrrolo[3,4-b]pyrrole | CHEMBL209106
Type:
Small organic molecule
Emp. Form.:
C12H15FN2
Mol. Mass.:
206.2593
SMILES:
Fc1cccc(c1)N1CC[C@H]2CNC[C@@H]12
Structure:
Search PDB for entries with ligand similarity: