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Target
Beta-1 adrenergic receptor
Ligand
BDBM50569859
Substrate
n/a
Meas. Tech.
ChEMBL_2249286 (CHEMBL5163496)
EC50
>100000±n/a nM
Citation
 Xing, G; Li, D; Woo, AY; Zhi, Z; Ji, L; Xing, R; Lv, H; He, B; An, H; Zhao, H; Lin, B; Pan, L; Cheng, M Discovery of a Highly Selective ? J Med Chem 65:5514-5527 (2022) [PubMed] 
Target
Name:
Beta-1 adrenergic receptor
Synonyms:
ADRB1 | ADRB1R | ADRB1_HUMAN | B1AR | Beta-1 adrenoceptor | Beta-1 adrenoreceptor | adrenergic Beta1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
51338.40
Organism:
Homo sapiens (Human)
Description:
P08588
Residue:
477
Sequence:
MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAPLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQGLLCCARRAARRRHATHGDRPRASGCLARPGPPPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFASESKV
  
Inhibitor
Name:
BDBM50569859
Synonyms:
CHEMBL4874511
Type:
Small organic molecule
Emp. Form.:
C13H18ClF3N2O
Mol. Mass.:
310.743
SMILES:
CC(C)(C)NC(CO)c1cc(Cl)c(N)c(c1)C(F)(F)F
Structure:
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