Reaction Details Report a problem with these data
Target
Phospholipase A2 group V
Ligand
BDBM50186585
Substrate
n/a
Meas. Tech.
ChEMBL_352638 (CHEMBL862130)
IC50
500±n/a nM
Citation
 Smart, BP; Oslund, RC; Walsh, LA; Gelb, MH The first potent inhibitor of mammalian group X secreted phospholipase A2: elucidation of sites for enhanced binding. J Med Chem 49:2858-60 (2006) [PubMed]  Article 
Target
Name:
Phospholipase A2 group V
Synonyms:
PA2G5_HUMAN | PLA2G5 | Phospholipase A2 group V | Secretory phospholipase A2, group V (sPLA2-V)
Type:
Protein
Mol. Mass.:
15682.61
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
138
Sequence:
MKGLLPLAWFLACSVPAVQGGLLDLKSMIEKVTGKNALTNYGFYGCYCGWGGRGTPKDGTDWCCWAHDHCYGRLEEKGCNIRTQSYKYRFAWGVVTCEPGPFCHVNLCACDRKLVYCLKRNLRSYNPQYQYFPNILCS
  
Inhibitor
Name:
BDBM50186585
Synonyms:
2-(3-(2-amino-2-oxoacetyl)-1-benzyl-2-ethyl-6-methyl-1H-indol-4-yloxy)acetic acid | CHEMBL208315
Type:
Small organic molecule
Emp. Form.:
C22H22N2O5
Mol. Mass.:
394.4205
SMILES:
CCc1c(C(=O)C(N)=O)c2c(OCC(O)=O)cc(C)cc2n1Cc1ccccc1
Structure:
Search PDB for entries with ligand similarity: