Reaction Details Report a problem with these data
Target
Group IIE secretory phospholipase A2
Ligand
BDBM50186585
Substrate
n/a
Meas. Tech.
ChEMBL_352636 (CHEMBL862127)
IC50
50±n/a nM
Citation
 Smart, BP; Oslund, RC; Walsh, LA; Gelb, MH The first potent inhibitor of mammalian group X secreted phospholipase A2: elucidation of sites for enhanced binding. J Med Chem 49:2858-60 (2006) [PubMed]  Article 
Target
Name:
Group IIE secretory phospholipase A2
Synonyms:
GIIE sPLA2 | PA2GE_HUMAN | PLA2G2E | Phosphatidylcholine 2-acylhydrolase GIIE | sPLA(2)-IIE
Type:
PROTEIN
Mol. Mass.:
15997.10
Organism:
Homo sapiens (Human)
Description:
ChEMBL_489274
Residue:
142
Sequence:
MKSPHVLVFLCLLVALVTGNLVQFGVMIEKMTGKSALQYNDYGCYCGIGGSHWPVDQTDWCCHAHDCCYGRLEKLGCEPKLEKYLFSVSERGIFCAGRTTCQRLTCECDKRAALCFRRNLGTYNRKYAHYPNKLCTGPTPPC
  
Inhibitor
Name:
BDBM50186585
Synonyms:
2-(3-(2-amino-2-oxoacetyl)-1-benzyl-2-ethyl-6-methyl-1H-indol-4-yloxy)acetic acid | CHEMBL208315
Type:
Small organic molecule
Emp. Form.:
C22H22N2O5
Mol. Mass.:
394.4205
SMILES:
CCc1c(C(=O)C(N)=O)c2c(OCC(O)=O)cc(C)cc2n1Cc1ccccc1
Structure:
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