Reaction Details Report a problem with these data
Target
Adenosine receptor A3
Ligand
BDBM50186599
Substrate
n/a
Meas. Tech.
ChEMBL_353094 (CHEMBL866938)
Ki
200±n/a nM
Citation
 Chang, LC; Spanjersberg, RF; von Frijtag Drabbe Künzel, JK; Mulder-Krieger, T; Brussee, J; Ijzerman, AP 2,6-disubstituted and 2,6,8-trisubstituted purines as adenosine receptor antagonists. J Med Chem 49:2861-7 (2006) [PubMed]  Article 
Target
Name:
Adenosine receptor A3
Synonyms:
A3 adenosine receptor (hA3) | AA3R_HUMAN | ADORA3 | Adenosine A3 receptor (A3AR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36197.32
Organism:
Homo sapiens (Human)
Description:
P0DMS8
Residue:
318
Sequence:
MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE
  
Inhibitor
Name:
BDBM50186599
Synonyms:
8-cyclohexyl-2,6-diphenyl-9H-purine | CHEMBL207529 | LUF-5957
Type:
Small organic molecule
Emp. Form.:
C23H22N4
Mol. Mass.:
354.4476
SMILES:
C1CCC(CC1)c1nc2nc(nc(-c3ccccc3)c2[nH]1)-c1ccccc1
Structure:
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