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Target
MAP kinase-interacting serine/threonine-protein kinase 1
Ligand
BDBM50130693
Substrate
n/a
Meas. Tech.
ChEMBL_2250352 (CHEMBL5164562)
IC50
1520±n/a nM
Citation
 Bou-Petit, E; Hümmer, S; Alarcon, H; Slobodnyuk, K; Cano-Galietero, M; Fuentes, P; Guijarro, PJ; Muñoz, MJ; Suarez-Cabrera, L; Santamaria, A; Estrada-Tejedor, R; Borrell, JI; Ramón Y Cajal, S Overcoming Paradoxical Kinase Priming by a Novel MNK1 Inhibitor. J Med Chem 65:6070-6087 (2022) [PubMed] 
Target
Name:
MAP kinase-interacting serine/threonine-protein kinase 1
Synonyms:
MAP Kinase-Interacting Protein Kinase (MNK1) | MAP kinase signal-integrating kinase 1 | MAP kinase-interacting serine/threonine-protein kinase 1 (MnK1) | MAP kinase-interacting serine/threonine-protein kinase MNK1 | MAP-kinase interacting kinase 1 (MNK1) | MAPK signal-integrating kinase 1 | MKNK1 | MKNK1_HUMAN | MNK1
Type:
Serine/threonine-protein kinase
Mol. Mass.:
51342.85
Organism:
Homo sapiens (Human)
Description:
Q9BUB5
Residue:
465
Sequence:
MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKDKVSLCHLGWSAMAPSGLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAPEKGLPTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENELAEEPEALADGLCSMKLSPPCKSRLARRRALAQAGRGEDRSPPTAL
  
Inhibitor
Name:
BDBM50130693
Synonyms:
CGP-57380 | CHEMBL1240885
Type:
Small organic molecule
Emp. Form.:
C11H9FN6
Mol. Mass.:
244.2278
SMILES:
Nc1ncnc2[nH]nc(Nc3ccc(F)cc3)c12
Structure:
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