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Target
Mitogen-activated protein kinase 7
Ligand
BDBM50605522
Substrate
n/a
Meas. Tech.
ChEMBL_2251880 (CHEMBL5166090)
IC50
60±n/a nM
Citation
 Miller, DC; Reuillon, T; Molyneux, L; Blackburn, T; Cook, SJ; Edwards, N; Endicott, JA; Golding, BT; Griffin, RJ; Hardcastle, I; Harnor, SJ; Heptinstall, A; Lochhead, P; Martin, MP; Martin, NC; Myers, S; Newell, DR; Noble, RA; Phillips, N; Rigoreau, L; Thomas, H; Tucker, JA; Wang, LZ; Waring, MJ; Wong, AC; Wedge, SR; Noble, MEM; Cano, C Parallel Optimization of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor. J Med Chem 65:6513-6540 (2022) [PubMed] 
Target
Name:
Mitogen-activated protein kinase 7
Synonyms:
BMK1 | Big MAP kinase 1 | ERK5 | Extracellular signal-regulated kinase 5 (ERK5) | MAPK7 | MK07_HUMAN | PRKM7
Type:
Protein
Mol. Mass.:
88377.36
Organism:
Homo sapiens (Human)
Description:
Q13164
Residue:
816
Sequence:
MAEPLKEEDGEDGSAEPPGPVKAEPAHTAASVAAKNLALLKARSFDVTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFHARREGIRQQIRFQPSLQPVASEPGCPDVEMPSPWAPSGDCAMESPPPAPPPCPGPAPDTIDLTLQPPPPVSEPAPPKKDGAISDNTKAALKAALLKSLRSRLRDGPSAPLEAPEPRKPVTAQERQREREEKRRRRQERAKEREKRRQERERKERGAGASGGPSTDPLAGLVLSDNDRSLLERWTRMARPAAPALTSVPAPAPAPTPTPTPVQPTSPPPGPVAQPTGPQPQSAGSTSGPVPQPACPPPGPAPHPTGPPGPIPVPAPPQIATSTSLLAAQSLVPPPGLPGSSTPGVLPYFPPGLPPPDAGGAPQSSMSESPDVNLVTQQLSKSQVEDPLPPVFSGTPKGSGAGYGVGFDLEEFLNQSFDMGVADGPQDGQADSASLSASLLADWLEGHGMNPADIESLQREIQMDSPMLLADLPDLQDP
  
Inhibitor
Name:
BDBM50605522
Synonyms:
CHEMBL5172952
Type:
Small organic molecule
Emp. Form.:
C21H19Cl2FN6O2
Mol. Mass.:
477.319
SMILES:
Fc1c(Cl)ccc(Cl)c1C(=O)c1c[nH]c(c1)C(=O)Nc1cnc(CN2CCNCC2)nc1
Structure:
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