Reaction Details Report a problem with these data
Target
Fibroblast growth factor receptor 4
Ligand
BDBM50606156
Substrate
n/a
Meas. Tech.
ChEMBL_2253894 (CHEMBL5168104)
IC50
0.700000±n/a nM
Citation
 Zhang, X; Wang, Y; Ji, J; Si, D; Bao, X; Yu, Z; Zhu, Y; Zhao, L; Li, W; Liu, J Discovery of 1,6-Naphthyridin-2(1 J Med Chem 65:7595-7618 (2022) [PubMed] 
Target
Name:
Fibroblast growth factor receptor 4
Synonyms:
CD_antigen: CD334 FGFR4 | FGFR-4 | FGFR4 | FGFR4_HUMAN | Fibroblast growth factor receptor | Fibroblast growth factor receptor 4 (FGFR4) | JK2 | JTK2 | TKF
Type:
Protein
Mol. Mass.:
87957.45
Organism:
Homo sapiens (Human)
Description:
P22455
Residue:
802
Sequence:
MRLLLALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRAERGGHWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDSLTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPTWTAAAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLARQFSLESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPSGGDASSTCSSSDSVFSHDPLPLGSSSFPFGSGVQT
  
Inhibitor
Name:
BDBM50606156
Synonyms:
CHEMBL5202677
Type:
Small organic molecule
Emp. Form.:
C28H26Cl2N4O5
Mol. Mass.:
569.436
SMILES:
CCn1c2cc(Nc3c(NC(=O)C=C)cccc3OC)ncc2cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c1=O |(-.67,-5,;.66,-4.24,;.66,-2.7,;-.66,-1.92,;-1.99,-2.7,;-3.33,-1.92,;-4.67,-2.7,;-6,-1.92,;-6,-.38,;-4.67,.38,;-4.67,1.92,;-3.33,2.7,;-6,2.7,;-6,4.24,;-7.33,.38,;-8.67,-.38,;-8.67,-1.92,;-7.33,-2.7,;-7.33,-4.23,;-5.99,-4.99,;-3.33,-.38,;-1.99,.38,;-.66,-.38,;.66,.38,;2,-.38,;3.33,.38,;4.67,-.38,;4.67,-1.92,;6.01,.38,;7.33,-.38,;8.67,.38,;6.01,1.92,;4.67,2.7,;4.67,4.24,;6.01,5,;3.33,1.92,;2,2.7,;2,-1.92,;3.33,-2.7,)|
Structure:
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