Reaction Details Report a problem with these data
Target
Fibroblast growth factor receptor 4
Ligand
BDBM50606159
Substrate
n/a
Meas. Tech.
ChEMBL_2253894 (CHEMBL5168104)
IC50
0.700000±n/a nM
Citation
 Zhang, X; Wang, Y; Ji, J; Si, D; Bao, X; Yu, Z; Zhu, Y; Zhao, L; Li, W; Liu, J Discovery of 1,6-Naphthyridin-2(1 J Med Chem 65:7595-7618 (2022) [PubMed] 
Target
Name:
Fibroblast growth factor receptor 4
Synonyms:
CD_antigen: CD334 FGFR4 | FGFR-4 | FGFR4 | FGFR4_HUMAN | Fibroblast growth factor receptor | Fibroblast growth factor receptor 4 (FGFR4) | JK2 | JTK2 | TKF
Type:
Protein
Mol. Mass.:
87957.45
Organism:
Homo sapiens (Human)
Description:
P22455
Residue:
802
Sequence:
MRLLLALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRAERGGHWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDSLTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPTWTAAAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLARQFSLESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPSGGDASSTCSSSDSVFSHDPLPLGSSSFPFGSGVQT
  
Inhibitor
Name:
BDBM50606159
Synonyms:
CHEMBL5186034
Type:
Small organic molecule
Emp. Form.:
C26H28Cl2N4O5
Mol. Mass.:
547.43
SMILES:
CCn1c2cc(N[C@@H]3COCC[C@@H]3NC(=O)C=C)ncc2cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c1=O |r,wU:7.6,12.13,(2,5.01,;.67,4.24,;.67,2.7,;-.67,1.93,;-2,2.7,;-3.33,1.93,;-4.67,2.7,;-6,1.93,;-7.33,2.7,;-8.67,1.93,;-8.67,.38,;-7.33,-.39,;-6,.38,;-4.67,-.39,;-4.67,-1.93,;-3.33,-2.7,;-6,-2.7,;-6,-4.24,;-3.33,.38,;-2,-.39,;-.67,.38,;.67,-.39,;2,.38,;3.34,-.39,;4.67,.38,;4.67,1.93,;6,-.39,;7.33,.38,;8.67,-.39,;6,-1.93,;4.67,-2.7,;4.67,-4.24,;6,-5.01,;3.34,-1.93,;2,-2.7,;2,1.93,;3.34,2.7,)|
Structure:
Search PDB for entries with ligand similarity: