Reaction Details Report a problem with these data
Target
Fibroblast growth factor receptor 4
Ligand
BDBM50606162
Substrate
n/a
Meas. Tech.
ChEMBL_2253894 (CHEMBL5168104)
IC50
2.6±n/a nM
Citation
 Zhang, X; Wang, Y; Ji, J; Si, D; Bao, X; Yu, Z; Zhu, Y; Zhao, L; Li, W; Liu, J Discovery of 1,6-Naphthyridin-2(1 J Med Chem 65:7595-7618 (2022) [PubMed] 
Target
Name:
Fibroblast growth factor receptor 4
Synonyms:
CD_antigen: CD334 FGFR4 | FGFR-4 | FGFR4 | FGFR4_HUMAN | Fibroblast growth factor receptor | Fibroblast growth factor receptor 4 (FGFR4) | JK2 | JTK2 | TKF
Type:
Protein
Mol. Mass.:
87957.45
Organism:
Homo sapiens (Human)
Description:
P22455
Residue:
802
Sequence:
MRLLLALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRAERGGHWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDSLTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPTWTAAAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLARQFSLESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPSGGDASSTCSSSDSVFSHDPLPLGSSSFPFGSGVQT
  
Inhibitor
Name:
BDBM50606162
Synonyms:
CHEMBL5193663
Type:
Small organic molecule
Emp. Form.:
C34H38Cl2N6O5
Mol. Mass.:
681.609
SMILES:
CCN1CCN(CC1)c1cc(NC(=O)C=C)c(Nc2cc3n(CC)c(=O)c(cc3cn2)-c2c(Cl)c(OC)cc(OC)c2Cl)c(OC)c1 |(-11.99,-1.92,;-10.65,-2.69,;-9.32,-1.92,;-7.98,-2.69,;-6.65,-1.92,;-6.65,-.39,;-7.98,.39,;-9.32,-.39,;-5.32,.39,;-4,-.39,;-2.66,.39,;-1.33,-.39,;-1.33,-1.92,;0,-2.69,;-2.66,-2.69,;-2.66,-4.23,;-2.66,1.92,;-1.33,2.69,;0,1.92,;1.34,2.69,;2.67,1.92,;4,2.69,;4,4.23,;5.33,5,;5.33,1.92,;6.66,2.69,;5.33,.39,;4,-.39,;2.67,.39,;1.34,-.39,;0,.39,;6.66,-.39,;7.99,.39,;7.99,1.92,;9.32,-.39,;10.65,.39,;11.99,-.39,;9.32,-1.92,;7.99,-2.69,;7.99,-4.23,;9.32,-5,;6.66,-1.92,;5.33,-2.69,;-4,2.69,;-4,4.22,;-5.33,4.99,;-5.32,1.92,)|
Structure:
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