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Target
Phosphatidylinositol 4-kinase type 2-alpha
Ligand
BDBM50607059
Substrate
n/a
Meas. Tech.
ChEMBL_2262078 (CHEMBL5217089)
IC50
1460±n/a nM
Citation
 Misehe, M; Klima, M; Matou?ová, M; Chalupská, D; Dejmek, M; ?ála, M; Mertlíková-Kaiserová, H; Boura, E; Nencka, R Structure-based design and modular synthesis of novel PI4K class II inhibitors bearing a 4-aminoquinazoline scaffold. Bioorg Med Chem Lett 76:0 (2022) [PubMed] 
Target
Name:
Phosphatidylinositol 4-kinase type 2-alpha
Synonyms:
P4K2A_HUMAN | PI4K2A | Phosphatidylinositol 4-kinase type 2-alpha | Phosphatidylinositol 4-kinase type II-alpha
Type:
PROTEIN
Mol. Mass.:
54030.26
Organism:
Homo sapiens (Human)
Description:
ChEMBL_104812
Residue:
479
Sequence:
MDETSPLVSPERAQPPDYTFPSGSGAHFPQVPGGAVRVAAAAGSGPSPPGSPGHDRERQPLLDRARGAAAQGQTQTVAAQAQALAAQAAAAAHAAQAHRERNEFPEDPEFEAVVRQAELAIERCIFPERIYQGSSGSYFVKDPQGRIIAVFKPKNEEPYGHLNPKWTKWLQKLCCPCCFGRDCLVLNQGYLSEAGASLVDQKLELNIVPRTKVVYLASETFNYSAIDRVKSRGKRLALEKVPKVGQRFNRIGLPPKVGSFQLFVEGYKDADYWLRRFEAEPLPENTNRQLLLQFERLVVLDYIIRNTDRGNDNWLIKYDCPMDSSSSRDTDWVVVKEPVIKVAAIDNGLAFPLKHPDSWRAYPFYWAWLPQAKVPFSQEIKDLILPKISDPNFVKDLEEDLYELFKKDPGFDRGQFHKQIAVMRGQILNLTQALKDNKSPLHLVQMPPVIVETARSHQRSSSESYTQSFQSRKPFFSWW
  
Inhibitor
Name:
BDBM50607059
Synonyms:
CHEMBL5220205
Type:
Small organic molecule
Emp. Form.:
C26H26N2O7
Mol. Mass.:
478.4938
SMILES:
CCCCc1cc(=O)oc2cc(OCC(=O)N[C@@H](Cc3c[nH]c4ccc(O)cc34)C(O)=O)ccc12 |r|
Structure:
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