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Target
Estrogen receptor beta
Ligand
BDBM50190350
Substrate
n/a
Meas. Tech.
ChEMBL_405016 (CHEMBL869284)
IC50
1±n/a nM
Citation
 Wildonger, KJ; Ratcliffe, RW; Mosley, RT; Hammond, ML; Birzin, ET; Rohrer, SP Tetrahydrofluorenones with conformationally restricted side chains as selective estrogen receptor beta ligands. Bioorg Med Chem Lett 16:4462-6 (2006) [PubMed]  Article 
Target
Name:
Estrogen receptor beta
Synonyms:
ER-beta | ESR2 | ESR2_HUMAN | ESTRB | Estradiol receptor beta (ERβ) | Estrogen receptor | Estrogen receptor (ER beta) | Estrogen receptor beta | Estrogen receptor beta (ER beta) | Estrogen receptor beta (ER) | NR3A2 | Nuclear receptor subfamily 3 group A member 2 | estrogen beta
Type:
Protein
Mol. Mass.:
59238.43
Organism:
Homo sapiens (Human)
Description:
Q92731
Residue:
530
Sequence:
MDIKNSPSSLNSPSSYNCSQSILPLEHGSIYIPSSYVDSHHEYPAMTFYSPAVMNYSIPSNVTNLEGGPGRQTTSPNVLWPTPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVNRETLKRKVSGNRCASPVTGPGSKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRLVRRQRSADEQLHCAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATQDADSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMKCKNVVPVYDLLLEMLNAHVLRGCKSSITGSECSPAEDSKSKEGSQNPQSQ
  
Inhibitor
Name:
BDBM50190350
Synonyms:
(1S,12R,14R)-5-hydroxy-10-methyl-14-propyltetracyclo[10.2.1.0^{1,9}.0^{3,8}]pentadeca-3,5,7,9-tetraen-11-one | CHEMBL379008
Type:
Small organic molecule
Emp. Form.:
C19H22O2
Mol. Mass.:
282.3768
SMILES:
CCC[C@@H]1C[C@@H]2C[C@]11Cc3cc(O)ccc3C1=C(C)C2=O |t:19|
Structure:
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