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Target
Cannabinoid receptor 1
Ligand
BDBM50303527
Substrate
n/a
Meas. Tech.
ChEMBL_2262392 (CHEMBL5217403)
Ki
44±n/a nM
Citation
 Callis, TB; Garrett, TR; Montgomery, AP; Danon, JJ; Kassiou, M Recent Scaffold Hopping Applications in Central Nervous System Drug Discovery. J Med Chem 65:13483-13504 (2022) [PubMed] 
Target
Name:
Cannabinoid receptor 1
Synonyms:
CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | CNR1_HUMAN | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
52868.96
Organism:
Homo sapiens (Human)
Description:
P21554
Residue:
472
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
  
Inhibitor
Name:
BDBM50303527
Synonyms:
(2,2,3,3-Tetramethylcyclopropyl)(1-(4,4,4-trifluorobutyl)-1Hindol-3-yl)methanone | CHEMBL569082
Type:
Small organic molecule
Emp. Form.:
C20H24F3NO
Mol. Mass.:
351.4059
SMILES:
CC1(C)C(C(=O)c2cn(CCCC(F)(F)F)c3ccccc23)C1(C)C
Structure:
Search PDB for entries with ligand similarity: