Reaction Details Report a problem with these data
Target
Melanin-concentrating hormone receptor 1
Ligand
BDBM50190854
Substrate
n/a
Meas. Tech.
ChEMBL_398818 (CHEMBL908038)
Ki
138±n/a nM
Citation
 Sasikumar, TK; Qiang, L; Wu, WL; Burnett, DA; Greenlee, WJ; O'Neill, K; Hawes, BE; van Heek, M; Graziano, M Tetrahydroisoquinolines as MCH-R1 antagonists. Bioorg Med Chem Lett 16:4917-21 (2006) [PubMed]  Article 
Target
Name:
Melanin-concentrating hormone receptor 1
Synonyms:
G-protein coupled receptor 24 | GPR24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCHR | MCHR-1 | MCHR1 | MCHR1_HUMAN | Melanin Concentrating Hormone 1 | Melanin-Concentrating Hormone Receptor 1 (MCH1R) | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 (MCH-1) | Melanin-concentrating hormone receptor 1 (MCH1) | Melanin-concentrating hormone receptor 1 (MCHR-1) | Melanin-concentrating hormone receptor 1 (MCHR1) | SLC-1 | SLC1 | Somatostatin receptor-like protein
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
45976.27
Organism:
Homo sapiens (Human)
Description:
Membranes from CHO-K1 cells stably expressing human MCH1R were used in assays.
Residue:
422
Sequence:
MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
  
Inhibitor
Name:
BDBM50190854
Synonyms:
CHEMBL212136 | N-(4-chloro-phenyl)-2-[6-(3-cyano-phenyl)-1'-cyclopropylmethyl-3,4-dihydro-spiro[isoquinoline-1,4'-piperidin]-2-yl]-acetamide
Type:
Small organic molecule
Emp. Form.:
C32H33ClN4O
Mol. Mass.:
525.084
SMILES:
Clc1ccc(NC(=O)CN2CCc3cc(ccc3C22CCN(CC3CC3)CC2)-c2cccc(c2)C#N)cc1
Structure:
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