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Target
Prostaglandin E2 receptor EP2 subtype
Ligand
BDBM50403532
Substrate
n/a
Meas. Tech.
ChEMBL_2264278
Ki
0.630000±n/a nM
Citation
 Sluter, MN; Hou, R; Li, L; Yasmen, N; Yu, Y; Liu, J; Jiang, J EP2 Antagonists (2011-2021): A Decade's Journey from Discovery to Therapeutics. J Med Chem 64:11816-11836 (2021) [PubMed] 
Target
Name:
Prostaglandin E2 receptor EP2 subtype
Synonyms:
PE2R2_HUMAN | PGE receptor EP2 subtype | PTGER2 | Prostaglandin E2 | Prostaglandin E2 receptor | Prostaglandin E2 receptor EP4 subtype | Prostanoid EP2 Receptor
Type:
Enzyme
Mol. Mass.:
39775.71
Organism:
Homo sapiens (Human)
Description:
P43116
Residue:
358
Sequence:
MGNASNDSQSEDCETRQWLPPGESPAISSVMFSAGVLGNLIALALLARRWRGDVGCSAGRRSSLSLFHVLVTELVFTDLLGTCLISPVVLASYARNQTLVALAPESRACTYFAFAMTFFSLATMLMLFAMALERYLSIGHPYFYQRRVSRSGGLAVLPVIYAVSLLFCSLPLLDYGQYVQYCPGTWCFIRHGRTAYLQLYATLLLLLIVSVLACNFSVILNLIRMHRRSRRSRCGPSLGSGRGGPGARRRGERVSMAEETDHLILLAIMTITFAVCSLPFTIFAYMNETSSRKEKWDLQALRFLSINSIIDPWVFAILRPPVLRLMRSVLCCRISLRTQDATQTSCSTQSDASKQADL
  
Inhibitor
Name:
BDBM50403532
Synonyms:
CHEMBL5285583
Type:
Small organic molecule
Emp. Form.:
C27H24N2O5
Mol. Mass.:
456.4899
SMILES:
COc1ccc(cc1)C(=O)N1CCC(COc2ccc(cc2)-c2ccc(cc2)C#N)(C1)C(O)=O
Structure:
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