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Target
Kinesin-like protein KIF18A
Ligand
BDBM50403557
Substrate
n/a
Meas. Tech.
ChEMBL_2264336
IC50
410±n/a nM
Citation
Tamayo, NA; Bourbeau, MP; Allen, JR; Ashton, KS; Chen, JJ; Kaller, MR; Nguyen, TT; Nishimura, N; Pettus, LH; Walton, M; Belmontes, B; Moriguchi, J; Chen, K; McCarter, JD; Hanestad, K; Chung, G; Ninniri, MSS; Sun, J; Poppe, L; Spahr, C; Hui, J; Jia, L; Wu, T; Dahal, UP; Edson, KZ; Payton, M Targeting the Mitotic Kinesin KIF18A in Chromosomally Unstable Cancers: Hit Optimization Toward an In Vivo Chemical Probe. J Med Chem 65:4972-4990 (2022) [PubMed]
More Info.:
Target
Name:
Kinesin-like protein KIF18A
Synonyms:
KI18A_HUMAN | KIF18A | Kinesin-like protein KIF18A | MS-KIF18A | Marrow stromal KIF18A
Type:
PROTEIN
Mol. Mass.:
102320.22
Organism:
Homo sapiens
Description:
ChEMBL_119153
Residue:
898
Sequence:
MSVTEEDLCHHMKVVVRVRPENTKEKAAGFHKVVHVVDKHILVFDPKQEEVSFFHGKKTTNQNVIKKQNKDLKFVFDAVFDETSTQSEVFEHTTKPILRSFLNGYNCTVLAYGATGAGKTHTMLGSADEPGVMYLTMLHLYKCMDEIKEEKICSTAVSYLEVYNEQIRDLLVNSGPLAVREDTQKGVVVHGLTLHQPKSSEEILHLLDNGNKNRTQHPTDMNATSSRSHAVFQIYLRQQDKTASINQNVRIAKMSLIDLAGSERASTSGAKGTRFVEGTNINRSLLALGNVINALADSKRKNQHIPYRNSKLTRLLKDSLGGNCQTIMIAAVSPSSVFYDDTYNTLKYANRAKDIKSSLKSNVLNVNNHITQYVKICNEQKAEILLLKEKLKAYEEQKAFTNENDQAKLMISNPQEKEIERFQEILNCLFQNREEIRQEYLKLEMLLKENELKSFYQQQCHKQIEMMCSEDKVEKATGKRDHRLAMLKTRRSYLEKRREEELKQFDENTNWLHRVEKEMGLLSQNGHIPKELKKDLHCHHLHLQNKDLKAQIRHMMDLACLQEQQHRQTEAVLNALLPTLRKQYCTLKEAGLSNAAFESDFKEIEHLVERKKVVVWADQTAEQPKQNDLPGISVLMTFPQLGPVQPIPCCSSSGGTNLVKIPTEKRTRRKLMPSPLKGQHTLKSPPSQSVQLNDSLSKELQPIVYTPEDCRKAFQNPSTVTLMKPSSFTTSFQAISSNINSDNCLKMLCEVAIPHNRRKECGQEDLDSTFTICEDIKSSKCKLPEQESLPNDNKDILQRLDPSSFSTKHSMPVPSMVPSYMAMTTAAKRKRKLTSSTSNSSLTADVNSGFAKRVRQDNSSEKHLQENKPTMEHKRNICKINPSMVRKFGRNISKGNLR