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Target
11-beta-hydroxysteroid dehydrogenase 1
Ligand
BDBM50192687
Substrate
n/a
Meas. Tech.
ChEMBL_422272 (CHEMBL855991)
IC50
149±n/a nM
Citation
 Yeh, VS; Kurukulasuriya, R; Madar, D; Patel, JR; Fung, S; Monzon, K; Chiou, W; Wang, J; Jacobson, P; Sham, HL; Link, JT Synthesis and structural activity relationship of 11beta-HSD1 inhibitors with novel adamantane replacements. Bioorg Med Chem Lett 16:5408-13 (2006) [PubMed]  Article 
Target
Name:
11-beta-hydroxysteroid dehydrogenase 1
Synonyms:
11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1
Type:
Enzyme
Mol. Mass.:
32409.16
Organism:
Homo sapiens (Human)
Description:
P28845
Residue:
292
Sequence:
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
  
Inhibitor
Name:
BDBM50192687
Synonyms:
(3r,9r)-9-(2-(4-chlorophenoxy)-2-methylpropanamido)bicyclo[3.3.1]nonane-3-carboxylic acid | CHEMBL386947
Type:
Small organic molecule
Emp. Form.:
C20H26ClNO4
Mol. Mass.:
379.878
SMILES:
CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2CCCC1C[C@H](C2)C(O)=O |wU:21.25,wD:14.14,TLB:13:14:18.17.16:22.21.20,23:21:18.17.16:14,(2.25,-20.96,;.92,-20.19,;-.44,-20.94,;2.25,-19.42,;2.25,-17.88,;3.59,-17.11,;3.59,-15.57,;2.26,-14.8,;2.26,-13.26,;.92,-15.58,;.92,-17.11,;-.42,-19.42,;-.41,-17.88,;-1.75,-20.18,;-3.08,-19.42,;-4.1,-20.22,;-3.98,-21.97,;-4.8,-22.91,;-3.34,-22.85,;-3.32,-20.9,;-5.09,-20.91,;-6.2,-21.69,;-5.79,-20.22,;-7.54,-20.91,;-7.54,-19.37,;-8.88,-21.69,)|
Structure:
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