Reaction Details Report a problem with these data
Target
Sphingolipid delta(4)-desaturase DES1
Ligand
BDBM50407241
Substrate
n/a
Meas. Tech.
ChEMBL_2266691
IC50
1680±n/a nM
Citation
 Skácel, J; Slusher, BS; Tsukamoto, T Small Molecule Inhibitors Targeting Biosynthesis of Ceramide, the Central Hub of the Sphingolipid Network. J Med Chem 64:279-297 (2021) [PubMed] 
Target
Name:
Sphingolipid delta(4)-desaturase DES1
Synonyms:
1.14.19.17 | 5.2.1.- | Degenerative spermatocyte homolog 1 | Degenerative spermatocyte-like protein RDES | Degs | Degs1 | Des1 | Dihydroceramide desaturase-1 | Retinol isomerase | Sphingolipid delta(4)-desaturase DES1
Type:
PROTEIN
Mol. Mass.:
38062.64
Organism:
Rattus norvegicus
Description:
ChEMBL_120919
Residue:
323
Sequence:
MGNRVSREEFEWVYTDQPHAARRQEILAKYPEIKSLMKPDPNLIWIVTSMLLVQLASFYLVKDLDWKWLMFWSYAFGSCLNHSMTLAIHEISHNFPFGHHKAMWNRWFGMFANLSLGVPYSISFKRYHMDHHRYLGADGIDVDIPTDFEGWFFCTTLRKLVWVILQPLFYAFRPLFINPKPITHLEVINTVIQVTFDVLVYYVFGVKSLVYMLAASLLGLGLHPISGHFIAEHYMFLKGHETYSYYGPLNLLTFNVGYHNEHHDFPNVPGKNLPLVRKIASEYYDNLPHYNSWIRVLYDFVMDDTISPYSRMKRPPKGNEIQE
  
Inhibitor
Name:
BDBM50407241
Synonyms:
CHEMBL5290345
Type:
Small organic molecule
Emp. Form.:
C26H31NO3
Mol. Mass.:
405.5292
SMILES:
C\C(\C=C\C1=C(C)C(=O)CCC1(C)C)=C/C=C/C(/C)=C/C(=O)Nc1ccc(O)cc1 |c:4|
Structure:
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