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Target
Peroxisome proliferator-activated receptor gamma
Ligand
BDBM50193746
Substrate
n/a
Meas. Tech.
ChEMBL_424080 (CHEMBL855083)
IC50
380±n/a nM
Citation
 Hopkins, CR; O'neil, SV; Laufersweiler, MC; Wang, Y; Pokross, M; Mekel, M; Evdokimov, A; Walter, R; Kontoyianni, M; Petrey, ME; Sabatakos, G; Roesgen, JT; Richardson, E; Demuth, TP Design and synthesis of novel N-sulfonyl-2-indole carboxamides as potent PPAR-gamma binding agents with potential application to the treatment of osteoporosis. Bioorg Med Chem Lett 16:5659-63 (2006) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor gamma
Synonyms:
NR1C3 | Nuclear receptor subfamily 1 group C member 3 | PPAR-gamma | PPARG | PPARG_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor gamma (PPAR gamma) | Peroxisome proliferator-activated receptor gamma (PPARG) | Peroxisome proliferator-activated receptor gamma (PPARĪ³) | Peroxisome proliferator-activated receptor gamma/Nuclear receptor corepressor 2 | peroxisome proliferator-activated receptor gamma isoform 2
Type:
Nuclear Receptor
Mol. Mass.:
57613.46
Organism:
Homo sapiens (Human)
Description:
P37231
Residue:
505
Sequence:
MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY
  
Inhibitor
Name:
BDBM50193746
Synonyms:
1-(2,5-dichlorobenzyl)-N-(3-(trifluoromethyl)phenylsulfonyl)-1H-indole-2-carboxamide | CHEMBL374705
Type:
Small organic molecule
Emp. Form.:
C23H15Cl2F3N2O3S
Mol. Mass.:
527.343
SMILES:
FC(F)(F)c1cccc(c1)S(=O)(=O)NC(=O)c1cc2ccccc2n1Cc1cc(Cl)ccc1Cl
Structure:
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