Reaction Details Report a problem with these data
Target
Sodium-dependent noradrenaline transporter
Ligand
BDBM50193762
Substrate
n/a
Meas. Tech.
ChEMBL_424087 (CHEMBL855090)
Ki
37±n/a nM
Citation
Watson, PS; Jiang, B; Harrison, K; Asakawa, N; Welch, PK; Covington, M; Stowell, NC; Wadman, EA; Davies, P; Solomon, KA; Newton, RC; Trainor, GL; Friedman, SM; Decicco, CP; Ko, SS 2,4-Disubstituted piperidines as selective CC chemokine receptor 3 (CCR3) antagonists: synthesis and selectivity. Bioorg Med Chem Lett 16:5695-9 (2006) [PubMed] Article
More Info.:
Target
Name:
Sodium-dependent noradrenaline transporter
Synonyms:
Monoamine transporter | NAT1 | NET | NET1 | Noradrenaline Transporter (NET) | Norepinephrine Transporter (NET) | Norepinephrine transporter protein (NET) | SC6A2_HUMAN | SLC6A2 | SLC6A5 | Sodium-dependent noradrenaline transporter (NET) | Solute carrier family 6 member 2
Type:
Multi-pass membrane protein
Mol. Mass.:
69337.72
Organism:
Homo sapiens (Human)
Description:
P23975
Residue:
617
Sequence:
MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTWNSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLCLMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFAIFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSSMGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINFKPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHLVAQRDIRQFQLQHWLAI
Inhibitor
Name:
BDBM50193762
Synonyms:
(+)1-(3-((2S,4R)-4-benzylpiperidin-2-yl)propyl)-3-(3-cyanophenyl)urea | (+/-)1-(3-((2S,4R)-4-benzylpiperidin-2-yl)propyl)-3-(3-cyanophenyl)urea | (-)1-(3-((2S,4R)-4-benzylpiperidin-2-yl)propyl)-3-(3-cyanophenyl)urea | CHEMBL218997
Type:
Small organic molecule
Emp. Form.:
C23H28N4O
Mol. Mass.:
376.4946
SMILES:
O=C(NCCC[C@H]1C[C@H](Cc2ccccc2)CCN1)Nc1cccc(c1)C#N