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Target
Gastrin/cholecystokinin type B receptor
Ligand
BDBM50196149
Substrate
n/a
Meas. Tech.
ChEMBL_418719 (CHEMBL912951)
Ki
>10000±n/a nM
Citation
 Allison, BD; Phuong, VK; McAtee, LC; Rosen, M; Morton, M; Prendergast, C; Barrett, T; Lagaud, G; Freedman, J; Li, L; Wu, X; Venkatesan, H; Pippel, M; Woods, C; Rizzolio, MC; Hack, M; Hoey, K; Deng, X; King, C; Shankley, NP; Rabinowitz, MH Identification and optimization of anthranilic sulfonamides as novel, selective cholecystokinin-2 receptor antagonists. J Med Chem 49:6371-90 (2006) [PubMed]  Article 
Target
Name:
Gastrin/cholecystokinin type B receptor
Synonyms:
CCK-2 receptor | CCK-B receptor | CCK-BR | CCKBR | CCKRB | Cholecystokinin A | Cholecystokinin receptor | Cholecystokinin-2 Receptor | GASR_HUMAN | Gastrin/cholecystokinin type B receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48445.79
Organism:
Homo sapiens (Human)
Description:
Stable expression of human CCK-2 receptors in HEK 293 cells.
Residue:
447
Sequence:
MELLKLNRSVQGTGPGPGASLCRPGAPLLNSSSVGNLSCEPPRIRGAGTRELELAIRITLYAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWLLSGLLMVPYPVYTVVQPVGPRVLQCVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGLISRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQNGRCRPETGAVGEDSDGCYVQLPRSRPALELTALTAPGPGSGSRPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDGPGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLETCARCCPRPPRARPRALPDEDPPTPSIASLSRLSYTTISTLGPG
  
Inhibitor
Name:
BDBM50196149
Synonyms:
4-[2-[(2,1,3-benzothiadiazol-4-ylsulfonyl)amino]benzoyl]-morpholine | CHEMBL217276
Type:
Small organic molecule
Emp. Form.:
C17H16N4O4S2
Mol. Mass.:
404.463
SMILES:
O=C(N1CCOCC1)c1ccccc1NS(=O)(=O)c1cccc2nsnc12
Structure:
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