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Target
Cytochrome P450 4F12
Ligand
BDBM50609596
Substrate
n/a
Meas. Tech.
ChEMBL_2278505
IC50
1598±n/a nM
Citation
 Yuan, Y; Yao, H; Zhou, M; Ma, X; Zhou, Y; Xu, J; Niu, M; Yin, J; Zheng, L; Xu, S Identification of a Novel Potent CYP4Z1 Inhibitor Attenuating the Stemness of Breast Cancer Cells through Lead Optimization. J Med Chem 65:15749-15769 (2022) [PubMed] 
Target
Name:
Cytochrome P450 4F12
Synonyms:
1.14.14.1 | CP4FC_HUMAN | CYP4F12 | CYPIVF12 | Cytochrome P450 4F12
Type:
PROTEIN
Mol. Mass.:
60317.77
Organism:
Homo sapiens
Description:
ChEMBL_109678
Residue:
524
Sequence:
MSLLSLPWLGLRPVATSPWLLLLLVVGSWLLARILAWTYAFYNNCRRLQCFPQPPKRNWFWGHLGLITPTEEGLKNSTQMSATYSQGFTVWLGPIIPFIVLCHPDTIRSITNASAAIAPKDNLFIRFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQHLASEGSSRLDMFEHISLMTLDSLQKCIFSFDSHCQERPSEYIATILELSALVEKRSQHILQHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFIDVLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITCLIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRFLPDHTEPRRKLELIMRAEGGLWLRVEPLNVSLQ
  
Inhibitor
Name:
BDBM50609596
Synonyms:
CHEMBL5272822
Type:
Small organic molecule
Emp. Form.:
C13H18N2O3
Mol. Mass.:
250.2936
SMILES:
CCOC(=O)CCCc1ccc(N\C=N\O)cc1
Structure:
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