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Target
Cyclin-dependent kinase 2
Ligand
BDBM50443288
Substrate
n/a
Meas. Tech.
ChEMBL_2281781
IC50
1850±n/a nM
Citation
 Alizadeh, SR; Ebrahimzadeh, MA Pyrazolotriazines: Biological activities, synthetic strategies and recent developments. Eur J Med Chem 223:0 (2021) [PubMed] 
Target
Name:
Cyclin-dependent kinase 2
Synonyms:
CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Homo sapiens (Human)
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Inhibitor
Name:
BDBM50443288
Synonyms:
CHEMBL5273636
Type:
Small organic molecule
Emp. Form.:
C21H18ClN5O2
Mol. Mass.:
407.853
SMILES:
CCOC(=O)c1cnn2c(nc(NCc3ccccc3)nc12)-c1ccc(Cl)cc1
Structure:
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