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Target
Polyphenol oxidase 2
Ligand
BDBM50610781
Substrate
n/a
Meas. Tech.
ChEMBL_2282141
Ki
4.0±n/a nM
Citation
 Li, J; Feng, L; Liu, L; Wang, F; Ouyang, L; Zhang, L; Hu, X; Wang, G Recent advances in the design and discovery of synthetic tyrosinase inhibitors. Eur J Med Chem 224:0 (2021) [PubMed] 
Target
Name:
Polyphenol oxidase 2
Synonyms:
Monophenol monooxygenase | Monophenol oxidase | PPO2 | PPO2_AGABI | Tyrosinase
Type:
Protein
Mol. Mass.:
63923.66
Organism:
Agaricus bisporus (Common mushroom)
Description:
O42713
Residue:
556
Sequence:
MSLIATVGPTGGVKNRLNIVDFVKNEKFFTLYVRSLELLQAKEQHDYSSFFQLAGIHGLPFTEWAKERPSMNLYKAGYCTHGQVLFPTWHRTYLSVLEQILQGAAIEVAKKFTSNQTDWVQAAQDLRQPYWDWGFELMPPDEVIKNEEVNITNYDGKKISVKNPILRYHFHPIDPSFKPYGDFATWRTTVRNPDRNRREDIPGLIKKMRLEEGQIREKTYNMLKFNDAWERFSNHGISDDQHANSLESVHDDIHVMVGYGKIEGHMDHPFFAAFDPIFWLHHTNVDRLLSLWKAINPDVWVTSGRNRDGTMGIAPNAQINSETPLEPFYQSGDKVWTSASLADTARLGYSYPDFDKLVGGTKELIRDAIDDLIDERYGSKPSSGARNTAFDLLADFKGITKEHKEDLKMYDWTIHVAFKKFELKESFSLLFYFASDGGDYDQENCFVGSINAFRGTAPETCANCQDNENLIQEGFIHLNHYLARDLESFEPQDVHKFLKEKGLSYKLYSRGDKPLTSLSVKIEGRPLHLPPGEHRPKYDHTQARVVFDDVAVHVIN
  
Inhibitor
Name:
BDBM50610781
Synonyms:
CHEMBL5277261
Type:
Small organic molecule
Emp. Form.:
C21H18ClFO4
Mol. Mass.:
388.817
SMILES:
CC1(C)CC(=O)C2=C(C1)Oc1c(oc(CCl)cc1=O)C2c1ccc(F)cc1 |c:6|
Structure:
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