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Target
Sphingosine 1-phosphate receptor 2
Ligand
BDBM50198835
Substrate
n/a
Meas. Tech.
ChEMBL_432836 (CHEMBL914104)
EC50
490±n/a nM
Citation
 Foss, FW; Snyder, AH; Davis, MD; Rouse, M; Okusa, MD; Lynch, KR; Macdonald, TL Synthesis and biological evaluation of gamma-aminophosphonates as potent, subtype-selective sphingosine 1-phosphate receptor agonists and antagonists. Bioorg Med Chem 15:663-77 (2006) [PubMed]  Article 
Target
Name:
Sphingosine 1-phosphate receptor 2
Synonyms:
EDG5 | S1P2 | S1PR2 | S1PR2_HUMAN | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor Edg-5 | Sphingosine-1-phosphate receptor 2 | ndothelial differentiation G-protein coupled receptor 5
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
38883.16
Organism:
Homo sapiens (Human)
Description:
Membranes isolated from S1P2-transfected CHO cells were used in ligand binding assay.
Residue:
353
Sequence:
MGSLYSEYLNPNKVQEHYNYTKETLETQETTSRQVASAFIVILCCAIVVENLLVLIAVARNSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGSVTLRLTPVQWFAREGSAFITLSASVFSLLAIAIERHVAIAKVKLYGSDKSCRMLLLIGASWLISLVLGGLPILGWNCLGHLEACSTVLPLYAKHYVLCVVTIFSIILLAIVALYVRIYCVVRSSHADMAAPQTLALLKTVTIVLGVFIVCWLPAFSILLLDYACPVHSCPILYKAHYFFAVSTLNSLLNPVIYTWRSRDLRREVLRPLQCWRPGVGVQGRRRGGTPGHHLLPLRSSSSLERGMHMPTSPTFLEGNTVV
  
Inhibitor
Name:
BDBM50198835
Synonyms:
CHEMBL226612 | [3-amino-3-(4-decylphenylcarbamoyl)-2-fluoropropyl]-phosphonic acid
Type:
Small organic molecule
Emp. Form.:
C20H34FN2O5P
Mol. Mass.:
432.4665
SMILES:
CCCCCCCCCCc1ccc(NC(=O)[C@H](N)CC(F)OP(O)(O)=O)cc1
Structure:
Search PDB for entries with ligand similarity: