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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50599877
Substrate
n/a
Meas. Tech.
ChEMBL_2289798
Ki
27±n/a nM
Citation
 Tolentino, KT; Mashinson, V; Sharma, MK; Chhonker, YS; Murry, DJ; Hopkins, CR From dopamine 4 to sigma 1: Synthesis, SAR and biological characterization of a piperidine scaffold of ?1 modulators. Eur J Med Chem 244:0 (2022) [PubMed] 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50599877
Synonyms:
CHEMBL5182602
Type:
Small organic molecule
Emp. Form.:
C21H22F3N3O
Mol. Mass.:
389.4141
SMILES:
FC(F)(F)c1cccc(COC2CCN(Cc3ccc4[nH]cnc4c3)CC2)c1
Structure:
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