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Target
Glucagon receptor
Ligand
BDBM50199501
Substrate
n/a
Meas. Tech.
ChEMBL_441038 (CHEMBL890125)
IC50
130±n/a nM
Citation
 Liang, R; Abrardo, L; Brady, EJ; Candelore, MR; Ding, V; Saperstein, R; Tota, LM; Wright, M; Mock, S; Tamvakopolous, C; Tong, S; Zheng, S; Zhang, BB; Tata, JR; Parmee, ER Design and synthesis of conformationally constrained tri-substituted ureas as potent antagonists of the human glucagon receptor. Bioorg Med Chem Lett 17:587-92 (2007) [PubMed]  Article 
Target
Name:
Glucagon receptor
Synonyms:
GCGR | GL-R | GLR_HUMAN | Glucagon Receptor (GCGR) | Glucagon receptor (GlucR)
Type:
Enzyme
Mol. Mass.:
54026.92
Organism:
Homo sapiens (Human)
Description:
P47871
Residue:
477
Sequence:
MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
  
Inhibitor
Name:
BDBM50199501
Synonyms:
3-(1-(N-((1r,4r)-4-tert-butylcyclohexyl)-4-(trifluoromethoxy)benzamido)-2,3-dihydro-1H-indene-5-carboxamido)propanoic acid | CHEMBL390469
Type:
Small organic molecule
Emp. Form.:
C31H37F3N2O5
Mol. Mass.:
574.6311
SMILES:
CC(C)(C)[C@H]1CC[C@@H](CC1)N(C1CCc2cc(ccc12)C(=O)NCCC(O)=O)C(=O)c1ccc(OC(F)(F)F)cc1 |w:11.11,wU:7.10,wD:4.3,(-1.59,-53.39,;-1.58,-51.85,;-.04,-51.86,;-3.12,-51.85,;-1.58,-50.31,;-.25,-49.54,;-.25,-47.99,;-1.58,-47.24,;-2.92,-48.01,;-2.91,-49.54,;-1.59,-45.7,;-.26,-44.92,;-.11,-43.38,;1.4,-43.06,;2.17,-44.39,;3.67,-44.7,;4.15,-46.15,;3.12,-47.3,;1.62,-46.98,;1.15,-45.53,;5.66,-46.46,;5.69,-48,;6.98,-45.67,;8.33,-46.42,;9.65,-45.63,;11,-46.38,;12.32,-45.59,;11.02,-47.92,;-2.93,-44.94,;-2.94,-43.4,;-4.26,-45.71,;-5.6,-44.95,;-6.92,-45.72,;-6.93,-47.27,;-8.26,-48.03,;-8.26,-49.57,;-8.27,-51.11,;-6.72,-49.58,;-9.8,-49.57,;-5.6,-48.04,;-4.25,-47.26,)|
Structure:
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