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Target
Sodium channel subunit beta-2
Ligand
BDBM50613344
Substrate
n/a
Meas. Tech.
ChEMBL_2291912
IC50
40±n/a nM
Citation
 Karanjule, N; Hayashi, N; Suzuki, S; Tsuda, T; Tokumaru, E; Tanaka, K; Kimoto, H; Domon, Y; Takahashi, S; Kubota, K; Kitano, Y; Yokoyama, T; Koishi, R; Fujiwara, C; Inaba, S; Asano, D; Sakakura, T; Takasuna, K; Shinozuka, T -Aryl Indoles as a Novel Class of Potent Na ACS Med Chem Lett 14:788-793 (2023) [PubMed] 
Target
Name:
Sodium channel subunit beta-2
Synonyms:
SCN2B | SCN2B_HUMAN | Sodium channel subunit beta-2
Type:
PROTEIN
Mol. Mass.:
24325.09
Organism:
Homo sapiens
Description:
ChEMBL_119884
Residue:
215
Sequence:
MHRDAWLPRPAFSLTGLSLFFSLVPPGRSMEVTVPATLNVLNGSDARLPCTFNSCYTVNHKQFSLNWTYQECNNCSEEMFLQFRMKIINLKLERFQDRVEFSGNPSKYDVSVMLRNVQPEDEGIYNCYIMNPPDRHRGHGKIHLQVLMEEPPERDSTVAVIVGASVGGFLAVVILVLMVVKCVRRKKEQKLSTDDLKTEEEGKTDGEGNPDDGAK
  
Inhibitor
Name:
BDBM50613344
Synonyms:
CHEMBL5284082
Type:
Small organic molecule
Emp. Form.:
C19H15F4N3O3S
Mol. Mass.:
441.399
SMILES:
Cc1cn(-c2cncc(c2)C(F)(F)F)c2cc(F)c(cc12)C(=O)NS(=O)(=O)C1CC1
Structure:
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