Reaction Details Report a problem with these data
Target
Melanocortin receptor 3
Ligand
BDBM50200355
Substrate
n/a
Meas. Tech.
ChEMBL_410062 (CHEMBL907163)
IC50
>1000±n/a nM
Citation
 Ying, J; Gu, X; Cai, M; Dedek, M; Vagner, J; Trivedi, DB; Hruby, VJ Design, synthesis, and biological evaluation of new cyclic melanotropin peptide analogues selective for the human melanocortin-4 receptor. J Med Chem 49:6888-96 (2006) [PubMed]  Article 
Target
Name:
Melanocortin receptor 3
Synonyms:
MC3-R | MC3R | MC3R_HUMAN | Melanocortin MC3 | Melanocortin receptor (M3 and M4)
Type:
Enzyme
Mol. Mass.:
36044.86
Organism:
Homo sapiens (Human)
Description:
P41968
Residue:
323
Sequence:
MNASCCLPSVQPTLPNGSEHLQAPFFSNQSSSAFCEQVFIKPEVFLSLGIVSLLENILVILAVVRNGNLHSPMYFFLCSLAVADMLVSVSNALETIMIAIVHSDYLTFEDQFIQHMDNIFDSMICISLVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALTLIVAIWVCCGVCGVVFIVYSESKMVIVCLITMFFAMMLLMGTLYVHMFLFARLHVKRIAALPPADGVAPQQHSCMKGAVTITILLGVFIFCWAPFFLHLVLIITCPTNPYCICYTAHFNTYLVLIMCNSVIDPLIYAFRSLELRNTFREILCGCNGMNLG
  
Inhibitor
Name:
BDBM50200355
Synonyms:
Ac-c[Glu-His-D-Phe-N-alpha-guanidinylbutyl-Dab]-Trp-NH2 | CHEMBL214477
Type:
Small organic molecule
Emp. Form.:
C42H55N13O7
Mol. Mass.:
853.969
SMILES:
CC(=O)N[C@H]1CCC(=O)NCCC(N(CCCCN=C(N)N)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O |wU:48.50,4.3,24.24,wD:35.36,(15.48,-8.37,;14.16,-7.58,;14.18,-6.04,;12.81,-8.32,;11.48,-7.53,;10.07,-8.33,;10.08,-9.82,;8.97,-10.3,;8.94,-11.84,;7.4,-9.54,;8.79,-5.95,;7.48,-5.14,;6.12,-5.87,;4.81,-5.06,;3.45,-5.78,;2.15,-4.97,;.79,-5.7,;-.52,-4.89,;-1.88,-5.61,;-3.19,-4.8,;-4.54,-5.53,;-3.14,-3.26,;4.86,-3.51,;3.55,-2.71,;6.22,-2.78,;6.27,-1.24,;4.95,-.44,;5,1.1,;3.69,1.91,;2.34,1.18,;2.3,-.37,;3.61,-1.17,;7.54,-3.59,;8.88,-2.83,;8.89,-1.28,;10.21,-3.61,;11.55,-2.85,;11.56,-1.31,;10.35,-.39,;10.84,1.07,;12.39,1.05,;12.84,-.43,;10.14,-5.23,;11.51,-5.98,;12.85,-5.21,;6.07,-7.41,;7.38,-8.22,;4.72,-8.14,;4.68,-9.68,;6.04,-10.41,;6.09,-11.95,;4.86,-12.89,;5.38,-14.34,;6.92,-14.3,;7.99,-15.41,;9.49,-15.04,;9.92,-13.56,;8.85,-12.45,;7.36,-12.82,;3.32,-10.42,;2.01,-9.62,;3.29,-11.96,)|
Structure:
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