Reaction Details Report a problem with these data
Target
Histone deacetylase 1
Ligand
BDBM50421841
Substrate
n/a
Meas. Tech.
ChEMBL_2299355
IC50
405±n/a nM
Citation
 Liu, T; Yao, X; Zhang, R; Wu, T; Liu, Z; Li, D; Dong, Q Design, synthesis and biological evaluation of novel indole-piperazine derivatives as antibacterial agents. Bioorg Med Chem Lett 89:0 (2023) [PubMed] 
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM50421841
Synonyms:
CHEMBL5270958
Type:
Small organic molecule
Emp. Form.:
C21H20N4O4
Mol. Mass.:
392.4079
SMILES:
ONC(=O)c1ccc(CN2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C2=O)cc1 |r|
Structure:
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