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Target
3-oxoacyl-[acyl-carrier-protein] synthase 3
Ligand
BDBM50201529
Substrate
n/a
Meas. Tech.
ChEMBL_441462 (CHEMBL891691)
IC50
>100000±n/a nM
Citation
 Alhamadsheh, MM; Waters, NC; Huddler, DP; Kreishman-Deitrick, M; Florova, G; Reynolds, KA Synthesis and biological evaluation of thiazolidine-2-one 1,1-dioxide as inhibitors of Escherichia coli beta-ketoacyl-ACP-synthase III (FabH). Bioorg Med Chem Lett 17:879-83 (2007) [PubMed]  Article 
Target
Name:
3-oxoacyl-[acyl-carrier-protein] synthase 3
Synonyms:
3-oxoacyl-[acyl-carrier-protein] synthase | 3-oxoacyl-[acyl-carrier-protein] synthase 3 | 3-oxoacyl-[acyl-carrier-protein] synthase III | Beta-ketoacyl-ACP synthase III (FabH)
Type:
Enzyme
Mol. Mass.:
33506.68
Organism:
Escherichia coli
Description:
C3TDZ2
Residue:
317
Sequence:
MYTKIIGTGSYLPEQVRTNADLEKMVDTSDEWIVTRTGIRERHIAAPNETVSTMGFEAATRAIEMAGIEKDQIGLIVVATTSATHAFPSAACQIQSMLGIKGCPAFDVAAACAGFTYALSVADQYVKSGAVKYALVVGSDVLARTCDPTDRGTIIIFGDGAGAAVLAASEEPGIISTHLHADGSYGELLTLPNADRVNPENSIHLTMAGNEVFKVAVTELAHIVDETLAANNLDRSQLDWLVPHQANLRIISATAKKLGMSMDNVVVTLDRHGNTSAASVPCALDEAVRDGRIKPGQLVLLEAFGGGFTWGSALVRF
  
Inhibitor
Name:
BDBM50201529
Synonyms:
3-phenethylthiazolidine-2-thione | CHEMBL232274
Type:
Small organic molecule
Emp. Form.:
C11H13NS2
Mol. Mass.:
223.358
SMILES:
S=C1SCCN1CCc1ccccc1
Structure:
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