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Target
Tyrosine-protein kinase HCK
Ligand
BDBM50202752
Substrate
n/a
Meas. Tech.
ChEMBL_446809 (CHEMBL897108)
IC50
>50000±n/a nM
Citation
 Abbott, L; Betschmann, P; Burchat, A; Calderwood, DJ; Davis, H; Hrnciar, P; Hirst, GC; Li, B; Morytko, M; Mullen, K; Yang, B Discovery of thienopyridines as Src-family selective Lck inhibitors. Bioorg Med Chem Lett 17:1167-71 (2007) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase HCK
Synonyms:
HCK | HCK_HUMAN | Hematopoietic cell kinase | Hemopoietic cell kinase | p59-HCK/p60-HCK | p59Hck | p61Hck
Type:
Enzyme Catalytic Domain
Mol. Mass.:
59600.18
Organism:
Homo sapiens (Human)
Description:
P08631
Residue:
526
Sequence:
MGGRSSCEDPGCPRDEERAPRMGCMKSKFLQVGGNTFSKTETSASPHCPVYVPDPTSTIKPGPNSHNSNTPGIREAGSEDIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSLATRKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATESQYQQQP
  
Inhibitor
Name:
BDBM50202752
Synonyms:
1-(4-amino-3-(3-methoxy-4-(1-methyl-1H-indole-2-carboxamido)phenyl)thieno[3,2-c]pyridin-7-yl)-3-(2-(pyrrolidin-1-yl)ethyl)urea | CHEMBL413486
Type:
Small organic molecule
Emp. Form.:
C31H33N7O3S
Mol. Mass.:
583.704
SMILES:
COc1cc(ccc1NC(=O)c1cc2ccccc2n1C)-c1csc2c(NC(=O)NCCN3CCCC3)cnc(N)c12
Structure:
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