Target
Malonyl-CoA decarboxylase, mitochondrial
Ligand
BDBM50202796
Substrate
n/a
Meas. Tech.
ChEMBL_454062 (CHEMBL903253)
IC50
304±n/a nM
Citation
 Wallace, DMHaramura, MCheng, JFArrhenius, TNadzan, AM Novel trifluoroacetophenone derivatives as malonyl-CoA decarboxylase inhibitors. Bioorg Med Chem Lett 17:1127-30 (2007) [PubMed]  Article 
Target
Name:
Malonyl-CoA decarboxylase, mitochondrial
Synonyms:
DCMC_HUMAN | MLYCD | Malonyl-CoA decarboxylase
Type:
PROTEIN
Mol. Mass.:
55018.37
Organism:
Homo sapiens (Human)
Description:
ChEMBL_665404
Residue:
493
Sequence:
MRGFGPGLTARRLLPLRLPPRPPGPRLASGQAAGALERAMDELLRRAVPPTPAYELREKTPAPAEGQCADFVSFYGGLAETAQRAELLGRLARGFGVDHGQVAEQSAGVLHLRQQQREAAVLLQAEDRLRYALVPRYRGLFHHISKLDGGVRFLVQLRADLLEAQALKLVEGPDVREMNGVLKGMLSEWFSSGFLNLERVTWHSPCEVLQKISEAEAVHPVKNWMDMKRRVGPYRRCYFFSHCSTPGEPLVVLHVALTGDISSNIQAIVKEHPPSETEEKNKITAAIFYSISLTQQGLQGVELGTFLIKRVVKELQREFPHLGVFSSLSPIPGFTKWLLGLLNSQTKEHGRNELFTDSECKEISEITGGPINETLKLLLSSSEWVQSEKLVRALQTPLMRLCAWYLYGEKHRGYALNPVANFHLQNGAVLWRINWMADVSLRGITGSCGLMANYRYFLEETGPNSTSYLGSKIIKASEQVLSLVAQFQKNSKL
  
Inhibitor
Name:
BDBM50202796
Synonyms:
CHEMBL396690 | N-(2-methylcyclohexyl)-4-(2,2,2-trifluoroacetyl)benzamide
Type:
Small organic molecule
Emp. Form.:
C16H18F3NO2
Mol. Mass.:
313.3148
SMILES:
CC1CCCCC1NC(=O)c1ccc(cc1)C(=O)C(F)(F)F |w:6.7,1.0|
Structure:
Search PDB for entries with ligand similarity: