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Target
Malonyl-CoA decarboxylase, mitochondrial
Ligand
BDBM50202806
Substrate
n/a
Meas. Tech.
ChEMBL_454062 (CHEMBL903253)
IC50
80±n/a nM
Citation
 Wallace, DM; Haramura, M; Cheng, JF; Arrhenius, T; Nadzan, AM Novel trifluoroacetophenone derivatives as malonyl-CoA decarboxylase inhibitors. Bioorg Med Chem Lett 17:1127-30 (2007) [PubMed]  Article 
Target
Name:
Malonyl-CoA decarboxylase, mitochondrial
Synonyms:
DCMC_HUMAN | MLYCD | Malonyl-CoA decarboxylase
Type:
PROTEIN
Mol. Mass.:
55018.37
Organism:
Homo sapiens (Human)
Description:
ChEMBL_665404
Residue:
493
Sequence:
MRGFGPGLTARRLLPLRLPPRPPGPRLASGQAAGALERAMDELLRRAVPPTPAYELREKTPAPAEGQCADFVSFYGGLAETAQRAELLGRLARGFGVDHGQVAEQSAGVLHLRQQQREAAVLLQAEDRLRYALVPRYRGLFHHISKLDGGVRFLVQLRADLLEAQALKLVEGPDVREMNGVLKGMLSEWFSSGFLNLERVTWHSPCEVLQKISEAEAVHPVKNWMDMKRRVGPYRRCYFFSHCSTPGEPLVVLHVALTGDISSNIQAIVKEHPPSETEEKNKITAAIFYSISLTQQGLQGVELGTFLIKRVVKELQREFPHLGVFSSLSPIPGFTKWLLGLLNSQTKEHGRNELFTDSECKEISEITGGPINETLKLLLSSSEWVQSEKLVRALQTPLMRLCAWYLYGEKHRGYALNPVANFHLQNGAVLWRINWMADVSLRGITGSCGLMANYRYFLEETGPNSTSYLGSKIIKASEQVLSLVAQFQKNSKL
  
Inhibitor
Name:
BDBM50202806
Synonyms:
2-(N-isobutyl-4-(2,2,2-trifluoroacetyl)benzamido)ethyl 3-nitrobenzoate | CHEMBL392724
Type:
Small organic molecule
Emp. Form.:
C22H21F3N2O6
Mol. Mass.:
466.4071
SMILES:
CC(C)CN(CCOC(=O)c1cccc(c1)[N+]([O-])=O)C(=O)c1ccc(cc1)C(=O)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: