Reaction Details Report a problem with these data
Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50203609
Substrate
n/a
Meas. Tech.
ChEMBL_454261 (CHEMBL903444)
Ki
11±n/a nM
Citation
 Han, X; Civiello, R; Pin, SS; Burris, K; Balanda, LA; Knipe, J; Ren, S; Fiedler, T; Browman, KE; Macci, R; Taber, MT; Zhang, J; Dubowchik, GM An orally active corticotropin releasing factor 1 receptor antagonist from 8-aryl-1,3a,7,8-tetraaza-cyclopenta[a]indenes. Bioorg Med Chem Lett 17:2026-30 (2007) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50203609
Synonyms:
CHEMBL247151 | allyl-[8-(2-chloro-4,6-dimethyl-phenyl)-2-methyl-8H-1,3a,7,8-tetraaza-cyclopenta[a]inden-3-ylmethyl]-propyl-amine
Type:
Small organic molecule
Emp. Form.:
C24H28ClN5
Mol. Mass.:
421.966
SMILES:
CCCN(CC=C)Cc1c(C)nc2n(-c3c(C)cc(C)cc3Cl)c3ncccc3n12 |(-10.99,4.06,;-10,2.89,;-8.48,3.16,;-7.49,1.98,;-5.97,2.25,;-5.45,3.7,;-3.93,3.97,;-8.01,.53,;-7.02,-.65,;-7.39,-2.14,;-8.82,-2.72,;-6.08,-2.95,;-4.91,-1.97,;-3.37,-1.86,;-2.38,-3.04,;-.87,-2.77,;-.35,-1.32,;.12,-3.94,;-.41,-5.4,;.59,-6.58,;-1.92,-5.66,;-2.91,-4.48,;-4.43,-4.75,;-2.99,-.37,;-1.62,.35,;-1.57,1.9,;-2.89,2.72,;-4.25,2,;-4.3,.46,;-5.48,-.54,)|
Structure:
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