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Target
Thymidine kinase
Ligand
BDBM50205237
Substrate
n/a
Meas. Tech.
ChEMBL_428150 (CHEMBL915787)
IC50
9000±n/a nM
Citation
 Chitneni, SK; Deroose, CM; Balzarini, J; Gijsbers, R; Celen, SJ; de Groot, TJ; Debyser, Z; Mortelmans, L; Verbruggen, AM; Bormans, GM Synthesis and preliminary evaluation of 18F- or 11C-labeled bicyclic nucleoside analogues as potential probes for imaging varicella-zoster virus thymidine kinase gene expression using positron emission tomography. J Med Chem 50:1041-9 (2007) [PubMed]  Article 
Target
Name:
Thymidine kinase
Synonyms:
KITH_HHV1 | TK | UL23
Type:
PROTEIN
Mol. Mass.:
40902.47
Organism:
Human herpesvirus 1 (strain SC16) (HHV-1) (Human herpes simplex virus1)
Description:
ChEMBL_474154
Residue:
376
Sequence:
MASYPCHQHASAFDQAARSRGHSNRRTALRPRRQQEATEVRLEQKMPTLLRVYIDGPHGMGKTTTTQLLVALGSRDDIVYVPEPMTYWQVLGASETIANIYTTQHRLDQGEISAGDAAVVMTSAQITMGMPYAVTDAVLAPHIGGEAGSSHAPPPALTLIFDRHPIAALLCYPAARYLMGSMTPQAVLAFVALIPPTLPGTNIVLGALPEDRHIDRLAKRQRPGERLDLAMLAAIRRVYGLLANTVRYLQGGGSWREDWGQLSGTAVPPQGAEPQSNAGPRPHIGDTLFTLFRAPELLAPNGDLYNVFAWALDVLAKRLRPMHVFILDYDQSPAGCRDALLQLTSGMVQTHVTTPGSIPTICDLARTFAREMGEAN
  
Inhibitor
Name:
BDBM50205237
Synonyms:
9-(4-fluoro-3-hydroxymethylbutyl)guanine | CHEMBL220519
Type:
Small organic molecule
Emp. Form.:
C10H14FN5O2
Mol. Mass.:
255.2489
SMILES:
Nc1nc2n(CCC(CO)CF)cnc2c(=O)[nH]1
Structure:
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